MORPHOLOGICAL AND CHEMICAL CHANGES IN BLOOD CELLS IN ACUTE LEUKAEMIA IN HUMANS NOTE 1. ANALYSIS OF BLOOD COUNTS IN PATIENTS WITH SUSPECTED ACUTE LEUKAEMIA PUBLISHEDOlga – Alina RADA, Corina Luminiţa MĂRAN, Mihaela OSTAN None email@example.com
Acute leukaemias are a heterogeneous group of clonal neoplastic nature with undifferentiated stem cells, or partially differentiated, characterized by stopping differentiation and maturation of these cells, associated or not with their passage in the peripheral blood. The disease has a high incidence, affecting all age groups. Investigate automatic CBC gives extremely precise and clear indications of the presence of a number of cells outside the limits of variation or of the presence of a distribution or abnormal morphology. Comparing the data obtained from processing CBC from patients investigated with biological reference values from literature the authors have found that leukocytes reached a value six times higher (602 %) than the maximum reference value; these values were associated with thrombocytopenia and hypochromia. In all evaluated patients, CBC signalled the presence of blasts and undifferentiated cells that motivate further investigation.
CBC, acute leukaemia, leukocytes, thrombocytopenia, hypochromia