The global antimicrobial resistance (AMR) crisis is a quintessential One Health challenge, intrinsically linking human, animal, and environmental health, with agriculture serving as a critical nexus. This research articulates a comprehensive, integrated One Health framework for mitigating AMR emergence and transmission within agricultural systems, focusing on livestock, aquaculture, and crop production. The research synthesizes evidence on the drivers of AMR in agriculture, including the prophylactic and metaphylactic use of antibiotics in animal production, the application of manure-based fertilizers containing resistant bacteria and genes, and the use of antimicrobials in plant pathology. We review a suite of synergistic interventions across the One Health spectrum: in animal health, promoting antibiotic stewardship through precision veterinary medicine, enhancing animal welfare and resilience via improved housing and nutrition, and deploying vaccines and probiotics as alternatives; in environmental health, implementing advanced manure and wastewater treatment technologies (e.g., anaerobic digestion, composting protocols) to degrade resistance genes, and managing agricultural runoff; and in human health, strengthening surveillance of resistant pathogens across the food chain and educating stakeholders on risk perception. The discussion critically evaluates the socio-economic, political, and behavioural barriers to implementing this holistic approach, including economic incentives for antibiotic use, regulatory fragmentation, and lack of cross-sectoral data sharing. We conclude that a systemic, preventive strategy, moving from a reactive, pathogen-centric model to a proactive, system-health model, is not only scientifically warranted but economically imperative. Effective AMR containment in agriculture requires breaking down disciplinary and institutional silos through integrated policy, transdisciplinary research, and aligned economic instruments that make responsible antimicrobial use the most viable choice for all stakeholders in the One Health continuum

agriculture, one health, antimicrobial, approach, combatting

agronomy

Presentation: poster